A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer

Oncolytic viruses armed with therapeutic transgenes of interest show great potential in cancer immunotherapy. Here, a novel oncolytic adenovirus carrying a signal regulatory protein‐α (SIRPα)‐IgG1 Fc fusion gene (termed SG635‐SF) was constructed, which could block the CD47 ‘don't eat me’ signal...

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Detalles Bibliográficos
Autores principales: Huang, Yao, Lv, Sai‐qun, Liu, Pin‐yi, Ye, Zhen‐long, Yang, Huan, Li, Lin‐fang, Zhu, Hai‐li, Wang, Ying, Cui, Lian‐zhen, Jiang, Du‐qing, Hao, Fang‐yuan, Xu, Hui‐min, Jin, Hua‐jun, Qian, Qi‐jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053234/
https://www.ncbi.nlm.nih.gov/pubmed/31899582
http://dx.doi.org/10.1002/1878-0261.12628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053234/
https://www.ncbi.nlm.nih.gov/pubmed/31899582
http://dx.doi.org/10.1002/1878-0261.12628

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