Cargando…

A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer

Oncolytic viruses armed with therapeutic transgenes of interest show great potential in cancer immunotherapy. Here, a novel oncolytic adenovirus carrying a signal regulatory protein‐α (SIRPα)‐IgG1 Fc fusion gene (termed SG635‐SF) was constructed, which could block the CD47 ‘don't eat me’ signal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yao, Lv, Sai‐qun, Liu, Pin‐yi, Ye, Zhen‐long, Yang, Huan, Li, Lin‐fang, Zhu, Hai‐li, Wang, Ying, Cui, Lian‐zhen, Jiang, Du‐qing, Hao, Fang‐yuan, Xu, Hui‐min, Jin, Hua‐jun, Qian, Qi‐jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053234/ https://www.ncbi.nlm.nih.gov/pubmed/31899582 http://dx.doi.org/10.1002/1878-0261.12628

Ejemplares similares

11R-P53 and GM-CSF Expressing Oncolytic Adenovirus Target Cancer Stem Cells with Enhanced Synergistic Activity
por: Lv, Sai-qun, et al.
Publicado: (2017)

Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy
por: Chen, Huanpeng, et al.
Publicado: (2022)

SIRPα blockade improves the antitumor immunity of radiotherapy in colorectal cancer
por: Ji, Kai, et al.
Publicado: (2023)

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma
por: Yang, Chunhua, et al.
Publicado: (2016)

Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells
por: Cheng, Pei-Hsin, et al.
Publicado: (2013)

Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer
por: Wang, Qiuman, et al.
Publicado: (2022)

The effects of radiation on antitumor efficacy of an oncolytic adenovirus vector in the Syrian hamster model
por: Young, Brittany A., et al.
Publicado: (2013)

Combined Treatment with an Oncolytic Adenovirus and Antitumor Activity of Vincristine against Retinoblastoma Cells
por: Song, Xin, et al.
Publicado: (2012)

Bifidobacterium affects antitumor efficacy of oncolytic adenovirus in a mouse model of melanoma
por: Tripodi, Lorella, et al.
Publicado: (2023)

Fc-gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment
por: Hirvinen, Mari, et al.
Publicado: (2013)

Interferon-α enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma
por: Wang, Cong-Jun, et al.
Publicado: (2012)

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35
por: Ono, Ryosuke, et al.
Publicado: (2021)

Oncolytic virus immunotherapies in ovarian cancer: moving beyond adenoviruses
por: Hoare, Joseph, et al.
Publicado: (2018)

NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer
por: Leung, Elaine Y.L., et al.
Publicado: (2020)

A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer
por: Liu, Jiayang, et al.
Publicado: (2022)

Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model
por: Xiao, Boduan, et al.
Publicado: (2017)

Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy
por: Ahn, Hyo Min, et al.
Publicado: (2016)

Antitumor effects of a dual cancer-specific oncolytic adenovirus on colorectal cancer in vitro and in vivo
por: YANG, GUOHUA, et al.
Publicado: (2015)

Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia
por: Wang, Zixuan, et al.
Publicado: (2020)

Strong antitumor efficacy of a pancreatic tumor‐targeting oncolytic adenovirus for neuroendocrine tumors
por: Yamamoto, Yuki, et al.
Publicado: (2017)

A Triple-Regulated Oncolytic Adenovirus Carrying MicroRNA-143 Exhibits Potent Antitumor Efficacy in Colorectal Cancer
por: Luo, Qifeng, et al.
Publicado: (2020)

An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells
por: Yuan, Sujing, et al.
Publicado: (2016)

SIRPαFc treatment targets human acute myeloid leukemia stem cells
por: Galkin, Oleksandr, et al.
Publicado: (2020)

Antitumor Effects of Oncolytic Adenovirus-Carrying siRNA Targeting Potential Oncogene EphA3
por: Zhao, Yali, et al.
Publicado: (2015)

SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal
por: Yu, Jifeng, et al.
Publicado: (2022)

Combination Therapy of Prostate Cancer by Oncolytic Adenovirus Harboring Interleukin 24 and Ionizing Radiation
por: Mao, Li-jun, et al.
Publicado: (2020)

Interleukin-24 enhancing antitumor activity of chimeric oncolytic adenovirus for treating acute promyelocytic leukemia cell
por: Liu, Li, et al.
Publicado: (2019)

Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance
por: Zhang, Hailin, et al.
Publicado: (2020)

A novel Golgi protein (GOLPH2)-regulated oncolytic adenovirus exhibits potent antitumor efficacy in hepatocellular carcinoma
por: Wang, Yigang, et al.
Publicado: (2015)

Oncolytic Adenoviruses in Gastrointestinal Cancers
por: Yokoda, Raquel T., et al.
Publicado: (2018)

Oncolytic Adenoviruses in Cancer Treatment
por: Alemany, Ramon
Publicado: (2014)

Oncolytic Adenovirus in Cancer Immunotherapy
por: Peter, Malin, et al.
Publicado: (2020)

Oncolytic Adenoviruses for Cancer Therapy
por: Tripodi, Lorella, et al.
Publicado: (2021)

Concepts in Oncolytic Adenovirus Therapy
por: Mantwill, Klaus, et al.
Publicado: (2021)

A Renaissance for Oncolytic Adenoviruses?
por: Blanchette, Paola, et al.
Publicado: (2023)

The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment
por: Hashimoto, Yuuri, et al.
Publicado: (2012)

The role of cyclophosphamide in enhancing antitumor efficacy of an adenovirus oncolytic vector in subcutaneous Syrian hamster tumors
por: Young, Brittany A., et al.
Publicado: (2013)

Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model
por: Rincón, Esther, et al.
Publicado: (2017)

Oncolytic Adenovirus: Prospects for Cancer Immunotherapy
por: Zhao, Yaqi, et al.
Publicado: (2021)

Synergistic antitumor effect of the combination of a dual cancer-specific oncolytic adenovirus and cisplatin on lung cancer cells
por: Jin, Jing, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ajohq8ho20b649rhtmd9tu4uq9