Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. I...

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Detalles Bibliográficos
Autores principales: Wang, Xinyi, Zhang, Haiyang, Yang, Haiou, Bai, Ming, Ning, Tao, Deng, Ting, Liu, Rui, Fan, Qian, Zhu, Kegan, Li, Jialu, Zhan, Yang, Ying, Guoguang, Ba, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053238/
https://www.ncbi.nlm.nih.gov/pubmed/31901148
http://dx.doi.org/10.1002/1878-0261.12629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053238/
https://www.ncbi.nlm.nih.gov/pubmed/31901148
http://dx.doi.org/10.1002/1878-0261.12629

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