Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

A phage‐derived human monoclonal antibody against VEGF‐C was developed as a potential anti‐tumor therapeutic and exhibited fast clearance in preclinical species, with notably faster clearance in serum than in plasma. The purpose of this work was to understand the factors contributing to its fast cle...

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Detalles Bibliográficos
Autores principales: Bumbaca Yadav, Daniela, Reyes, Arthur E., Gupta, Priyanka, Vernes, Jean‐Michel, Meng, Y. Gloria, Schweiger, Michelle G., Stainton, Shannon L., Fuh, Germaine, Fielder, Paul J., Kamath, Amrita V., Shen, Ben‐Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053556/
https://www.ncbi.nlm.nih.gov/pubmed/32125783
http://dx.doi.org/10.1002/prp2.573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053556/
https://www.ncbi.nlm.nih.gov/pubmed/32125783
http://dx.doi.org/10.1002/prp2.573

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