The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors

The aim was to determine whether the neuroprotective effect of SIRT1 in Alzheimer’s disease (AD), due to inhibition of aggregation of the β-amyloid peptide (Aβ), involves activation of α7 nAChR. In present study, four-month-old APP/PS1 mice were administered resveratrol (RSV) or suramin once daily f...

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Detalles Bibliográficos
Autores principales: Cao, Kun, Dong, Yang-Ting, Xiang, Jie, Xu, Yi, Li, Yi, Song, Hui, Yu, Wen-Feng, Qi, Xiao-Lan, Guan, Zhi-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053601/
https://www.ncbi.nlm.nih.gov/pubmed/32003755
http://dx.doi.org/10.18632/aging.102713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053601/
https://www.ncbi.nlm.nih.gov/pubmed/32003755
http://dx.doi.org/10.18632/aging.102713

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