Mammalian ALKBH1 serves as an N(6)-mA demethylase of unpairing DNA

N(6)-methyladenine (N(6)-mA) of DNA is an emerging epigenetic mark in mammalian genome. Levels of N(6)-mA undergo drastic fluctuation during early embryogenesis, indicative of active regulation. Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N(6)-mA...

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Detalles Bibliográficos
Autores principales: Zhang, Min, Yang, Shumin, Nelakanti, Raman, Zhao, Wentao, Liu, Gaochao, Li, Zheng, Liu, Xiaohui, Wu, Tao, Xiao, Andrew, Li, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054317/
https://www.ncbi.nlm.nih.gov/pubmed/32051560
http://dx.doi.org/10.1038/s41422-019-0237-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054317/
https://www.ncbi.nlm.nih.gov/pubmed/32051560
http://dx.doi.org/10.1038/s41422-019-0237-5

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