The mTOR pathway is necessary for survival of mice with short telomeres

Telomerase deficiency leads to age-related diseases and shorter lifespans. Inhibition of the mechanistic target of rapamycin (mTOR) delays aging and age-related pathologies. Here, we show that telomerase deficient mice with short telomeres (G2-Terc(−/−)) have an hyper-activated mTOR pathway with inc...

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Detalles Bibliográficos
Autores principales: Ferrara-Romeo, Iole, Martinez, Paula, Saraswati, Sarita, Whittemore, Kurt, Graña-Castro, Osvaldo, Thelma Poluha, Lydia, Serrano, Rosa, Hernandez-Encinas, Elena, Blanco-Aparicio, Carmen, Maria Flores, Juana, Blasco, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054554/
https://www.ncbi.nlm.nih.gov/pubmed/32127537
http://dx.doi.org/10.1038/s41467-020-14962-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054554/
https://www.ncbi.nlm.nih.gov/pubmed/32127537
http://dx.doi.org/10.1038/s41467-020-14962-1

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