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The mTOR pathway is necessary for survival of mice with short telomeres
Telomerase deficiency leads to age-related diseases and shorter lifespans. Inhibition of the mechanistic target of rapamycin (mTOR) delays aging and age-related pathologies. Here, we show that telomerase deficient mice with short telomeres (G2-Terc(−/−)) have an hyper-activated mTOR pathway with inc...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054554/ https://www.ncbi.nlm.nih.gov/pubmed/32127537 http://dx.doi.org/10.1038/s41467-020-14962-1 |