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IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons

Signalling endosomes are essential for trafficking of activated ligand–receptor complexes and their distal signalling, ultimately leading to neuronal survival. Although deficits in signalling endosome transport have been linked to neurodegeneration, our understanding of the mechanisms controlling th...

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Detalles Bibliográficos
Autores principales: Fellows, Alexander D, Rhymes, Elena R, Gibbs, Katherine L, Greensmith, Linda, Schiavo, Giampietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054680/
https://www.ncbi.nlm.nih.gov/pubmed/32030864
http://dx.doi.org/10.15252/embr.201949129