A revised model of TRAIL‐R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

The long FLIP splice form FLIP(L) can act as both an inhibitor and promoter of caspase‐8 at death‐inducing signalling complexes (DISCs) formed by death receptors such as TRAIL‐R2 and related intracellular complexes such as the ripoptosome. Herein, we describe a revised DISC assembly model that expla...

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Detalles Bibliográficos
Autores principales: Humphreys, Luke M, Fox, Jennifer P, Higgins, Catherine A, Majkut, Joanna, Sessler, Tamas, McLaughlin, Kirsty, McCann, Christopher, Roberts, Jamie Z, Crawford, Nyree T, McDade, Simon S, Scott, Christopher J, Harrison, Timothy, Longley, Daniel B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054686/
https://www.ncbi.nlm.nih.gov/pubmed/32009295
http://dx.doi.org/10.15252/embr.201949254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054686/
https://www.ncbi.nlm.nih.gov/pubmed/32009295
http://dx.doi.org/10.15252/embr.201949254

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