Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans

With the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) approvals for Zolgensma, Luxturna, and Glybera, recombinant adeno-associated viruses (rAAVs) are considered efficient tools for gene transfer. However, studies in animals and humans demonstrate that intramuscular (IM)...

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Detalles Bibliográficos
Autores principales: Gernoux, Gwladys, Gruntman, Alisha M., Blackwood, Meghan, Zieger, Marina, Flotte, Terence R., Mueller, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054721/
https://www.ncbi.nlm.nih.gov/pubmed/31982038
http://dx.doi.org/10.1016/j.ymthe.2020.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054721/
https://www.ncbi.nlm.nih.gov/pubmed/31982038
http://dx.doi.org/10.1016/j.ymthe.2020.01.004

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