Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)

Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sites for arginine substrate and the cofactor (S-aden...

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Detalles Bibliográficos
Autores principales: Gunnell, Emma A., Al-Noori, Alaa, Muhsen, Usama, Davies, Clare C., Dowden, James, Dreveny, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054760/
https://www.ncbi.nlm.nih.gov/pubmed/32011657
http://dx.doi.org/10.1042/BCJ20190826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054760/
https://www.ncbi.nlm.nih.gov/pubmed/32011657
http://dx.doi.org/10.1042/BCJ20190826

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