Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

Recent interest in astrocyte activation states has raised the fundamental question of how these cells, normally essential for synapse and neuronal maintenance, become pathogenic. Here, we show that activation of the unfolded protein response (UPR), specifically phosphorylated protein kinase R-like e...

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Detalles Bibliográficos
Autores principales: Smith, Heather L., Freeman, Oliver J., Butcher, Adrian J., Holmqvist, Staffan, Humoud, Ibrahim, Schätzl, Tobias, Hughes, Daniel T., Verity, Nicholas C., Swinden, Dean P., Hayes, Joseph, de Weerd, Lis, Rowitch, David H., Franklin, Robin J.M., Mallucci, Giovanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054837/
https://www.ncbi.nlm.nih.gov/pubmed/31924446
http://dx.doi.org/10.1016/j.neuron.2019.12.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054837/
https://www.ncbi.nlm.nih.gov/pubmed/31924446
http://dx.doi.org/10.1016/j.neuron.2019.12.014

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