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Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration
Recent interest in astrocyte activation states has raised the fundamental question of how these cells, normally essential for synapse and neuronal maintenance, become pathogenic. Here, we show that activation of the unfolded protein response (UPR), specifically phosphorylated protein kinase R-like e...
Autores principales: | Smith, Heather L., Freeman, Oliver J., Butcher, Adrian J., Holmqvist, Staffan, Humoud, Ibrahim, Schätzl, Tobias, Hughes, Daniel T., Verity, Nicholas C., Swinden, Dean P., Hayes, Joseph, de Weerd, Lis, Rowitch, David H., Franklin, Robin J.M., Mallucci, Giovanna R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054837/ https://www.ncbi.nlm.nih.gov/pubmed/31924446 http://dx.doi.org/10.1016/j.neuron.2019.12.014 |
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