Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of Na(V)1.5 Channels

Acute cardiac hypoxia produces life-threatening elevations in late sodium current (I(LATE)) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of Na(V)1.5 channels so they reopen when normally inactive, late in the action potential. Na(V)1.5 is SUMOylated o...

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Detalles Bibliográficos
Autores principales: Plant, Leigh D., Xiong, Dazhi, Romero, Jesus, Dai, Hui, Goldstein, Steve A.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054841/
https://www.ncbi.nlm.nih.gov/pubmed/32075761
http://dx.doi.org/10.1016/j.celrep.2020.01.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054841/
https://www.ncbi.nlm.nih.gov/pubmed/32075761
http://dx.doi.org/10.1016/j.celrep.2020.01.025

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