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Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds

Phosphatidic acid (PA) is both a central phospholipid biosynthetic intermediate and a multifunctional lipid second messenger produced at several discrete subcellular locations. Organelle-specific PA pools are believed to play distinct physiological roles, but tools with high spatiotemporal control a...

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Detalles Bibliográficos
Autores principales: Tei, Reika, Baskin, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054994/
https://www.ncbi.nlm.nih.gov/pubmed/31999306
http://dx.doi.org/10.1083/jcb.201907013