Cargando…

High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance

BACKGROUND: Recently, targeted therapy for malignant tumors has developed rapidly, but there is still no effective targeted therapy for advanced esophageal squamous cell carcinoma (ESCC). Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a key enzyme involved in folate metabolism and is closely...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Huan, Li, Peng-Cheng, Jia, Wei, Hu, Bing, Ji, Chu-Shu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2020
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055195/ https://www.ncbi.nlm.nih.gov/pubmed/32088725 http://dx.doi.org/10.12659/MSM.920259

Ejemplares similares

The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)
por: Zhao, Li Na, et al.
Publicado: (2022)

Expression and Prognostic Value Identification of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Brain Low-Grade Glioma
por: Shi, Lu-feng, et al.
Publicado: (2021)

Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)
por: Lee, Lung-Chun, et al.
Publicado: (2021)

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
por: Shin, Minhye, et al.
Publicado: (2017)

Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer
por: Eich, Marie-Lisa, et al.
Publicado: (2019)

The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma
por: Cui, Li, et al.
Publicado: (2020)

Methylenetetrahydrofolate dehydrogenase (MTHFD) enzyme polymorphism as a maternal risk factor for trisomy 21: a clinical study
por: Neagos, D, et al.
Publicado: (2010)

miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia
por: Gu, Yueli, et al.
Publicado: (2017)

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach
por: Rana, Nisarg, et al.
Publicado: (2023)

Coexpression of periostin and EGFR in patients with esophageal squamous cell carcinoma and their prognostic significance
por: Jia, Wei, et al.
Publicado: (2016)

Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis
por: He, Donglin, et al.
Publicado: (2018)

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma
por: Yang, Bo, et al.
Publicado: (2018)

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2
por: Asai, Ayumu, et al.
Publicado: (2018)

NAD-dependent methylenetetrahydrofolate dehydrogenase inhibits oral squamous cell carcinoma cell proliferation and promotes apoptosis
por: Zhao, Liang, et al.
Publicado: (2021)

Prognostic and diagnostic potential of isocitrate dehydrogenase 1 in esophageal squamous cell carcinoma
por: Chen, Xuan, et al.
Publicado: (2016)

Prognostic significance of preoperative IKBKE expression in esophageal squamous cell carcinoma
por: Yang, Wenjing, et al.
Publicado: (2018)

Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer
por: Horiguchi, J, et al.
Publicado: (2002)

MTHFD2- a new twist?
por: Tedeschi, Philip M., et al.
Publicado: (2016)

Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma
por: Wang, Jian-Hua, et al.
Publicado: (2017)

Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma
por: Yang, Yu-Shang, et al.
Publicado: (2017)

Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease
por: Liu, Hanjun, et al.
Publicado: (2023)

The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma
por: Sarbia, M, et al.
Publicado: (2006)

Significance of the prognostic nutritional index in patients with esophageal squamous cell carcinoma
por: Feng, Ji-Feng, et al.
Publicado: (2013)

Targeting MTHFD2 in acute myeloid leukemia
por: Pikman, Yana, et al.
Publicado: (2016)

Prognostic Significance of Periostin and Mammalian Target of Rapamycin (mTOR) in Locally Advanced Esophageal Squamous Cell Carcinoma
por: Jiang, Qi, et al.
Publicado: (2017)

Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma
por: Lei, Zhijin, et al.
Publicado: (2016)

Prognostic value of lactate dehydrogenase to albumin ratio (LAR) in patients with resectable esophageal squamous cell carcinoma
por: Feng, Ji-Feng, et al.
Publicado: (2019)

Identification of MTHFD2 as a novel prognosis biomarker in esophageal carcinoma patients based on transcriptomic data and methylation profiling
por: Wang, Jianlin, et al.
Publicado: (2020)

Crystal structure of Thermus thermophilus methylenetetrahydrofolate dehydrogenase and determinants of thermostability
por: Maiello, Fernando, et al.
Publicado: (2020)

Prognostic Significance of Glasgow Prognostic Score in Patients Undergoing Esophagectomy for Esophageal Squamous Cell Carcinoma
por: Feng, Ji-Feng, et al.
Publicado: (2014)

Metastatic to negative lymph node ratio demonstrates significant prognostic value in patients with esophageal squamous cell carcinoma after esophagectomy
por: Duan, Xiao-Feng, et al.
Publicado: (2017)

Prognostic Significance of Baseline Neutrophil Count and Lactate Dehydrogenase Level in Patients With Esophageal Squamous Cell Cancer Treated With Radiotherapy
por: Luo, He-San, et al.
Publicado: (2020)

Prognostic Significance of the Lung Immune Prognostic Index in Patients with Resected Esophageal Squamous Cell Carcinoma
por: Feng, Ji-Feng, et al.
Publicado: (2021)

Prognostic Relevance of Methylenetetrahydrofolate Reductase Polymorphisms for Prostate Cancer
por: Lin, Victor C., et al.
Publicado: (2016)

Identification of MTHFD2 as a prognostic biomarker and ferroptosis regulator in triple-negative breast cancer
por: Zhang, Hao, et al.
Publicado: (2023)

Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma
por: Guo, Erliang, et al.
Publicado: (2020)

Prognostic Value of Lactate Dehydrogenase in Second-Line Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma
por: Li, Yan, et al.
Publicado: (2022)

The Emerging Role of MTHFD Family Genes in Regulating the Tumor Immunity of Oral Squamous Cell Carcinoma
por: Wang, Wei, et al.
Publicado: (2022)

The Prognostic Significance of Cancer-Associated Fibroblasts in Esophageal Squamous Cell Carcinoma
por: Ha, Sang Yun, et al.
Publicado: (2014)

Prognostic significance of FAM3C in esophageal squamous cell carcinoma
por: Zhu, Ying-Hui, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_u8td6gqoor8hjqqoeet2g9ph08