Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation

Paclitaxel induces peripheral neuropathy as a side effect of cancer treatment. The underlying causes are unclear, but epidermal, unmyelinated axons have been shown to be the first to degenerate. We previously utilized an in vivo zebrafish model to show that the epidermal matrix-metalloproteinase 13...

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Detalles Bibliográficos
Autores principales: Cirrincione, Anthony M., Pellegrini, Adriana D., Dominy, Jessica R., Benjamin, Marisa E., Utkina-Sosunova, Irina, Lotti, Francesco, Jergova, Stanislava, Sagen, Jacqueline, Rieger, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055229/
https://www.ncbi.nlm.nih.gov/pubmed/32132628
http://dx.doi.org/10.1038/s41598-020-60990-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055229/
https://www.ncbi.nlm.nih.gov/pubmed/32132628
http://dx.doi.org/10.1038/s41598-020-60990-8

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