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Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation
Paclitaxel induces peripheral neuropathy as a side effect of cancer treatment. The underlying causes are unclear, but epidermal, unmyelinated axons have been shown to be the first to degenerate. We previously utilized an in vivo zebrafish model to show that the epidermal matrix-metalloproteinase 13...
Autores principales: | Cirrincione, Anthony M., Pellegrini, Adriana D., Dominy, Jessica R., Benjamin, Marisa E., Utkina-Sosunova, Irina, Lotti, Francesco, Jergova, Stanislava, Sagen, Jacqueline, Rieger, Sandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055229/ https://www.ncbi.nlm.nih.gov/pubmed/32132628 http://dx.doi.org/10.1038/s41598-020-60990-8 |
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