Basic Limonoid modulates Chaperone-mediated Proteostasis and dissolve Tau fibrils

The Alzheimer’s disease pathology is associated with accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. The formation of initial nucleus triggers conformational changes in Tau and leads to its deposition. Hence, there is a need to eliminate these toxic proteins f...

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Detalles Bibliográficos
Autores principales: Gorantla, Nalini Vijay, Das, Rashmi, Chidambaram, Hariharakrishnan, Dubey, Tushar, Mulani, Fayaj A., Thulasiram, Hirekodathakallu V., Chinnathambi, Subashchandrabose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055235/
https://www.ncbi.nlm.nih.gov/pubmed/32132570
http://dx.doi.org/10.1038/s41598-020-60773-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055235/
https://www.ncbi.nlm.nih.gov/pubmed/32132570
http://dx.doi.org/10.1038/s41598-020-60773-1

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