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Basic Limonoid modulates Chaperone-mediated Proteostasis and dissolve Tau fibrils
The Alzheimer’s disease pathology is associated with accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. The formation of initial nucleus triggers conformational changes in Tau and leads to its deposition. Hence, there is a need to eliminate these toxic proteins f...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055235/ https://www.ncbi.nlm.nih.gov/pubmed/32132570 http://dx.doi.org/10.1038/s41598-020-60773-1 |