Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

The ability to prevent blood loss in response to injury is a conserved function of all vertebrates. Complete deficiency of the central clotting enzyme prothrombin has never been observed in humans and is incompatible with postnatal life in mice, thus limiting the ability to study its role in vivo. Z...

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Detalles Bibliográficos
Autores principales: Grzegorski, Steven J., Hu, Zhilian, Liu, Yang, Yu, Xinge, Ferguson, Allison C., Madarati, Hasam, Friedmann, Alexander P., Reyon, Deepak, Kim, Paul Y., Kretz, Colin A., Joung, J. Keith, Shavit, Jordan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055286/
https://www.ncbi.nlm.nih.gov/pubmed/32132579
http://dx.doi.org/10.1038/s41598-020-60840-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055286/
https://www.ncbi.nlm.nih.gov/pubmed/32132579
http://dx.doi.org/10.1038/s41598-020-60840-7

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