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Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish
The ability to prevent blood loss in response to injury is a conserved function of all vertebrates. Complete deficiency of the central clotting enzyme prothrombin has never been observed in humans and is incompatible with postnatal life in mice, thus limiting the ability to study its role in vivo. Z...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055286/ https://www.ncbi.nlm.nih.gov/pubmed/32132579 http://dx.doi.org/10.1038/s41598-020-60840-7 |