A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus

Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that SLE-prone mice (CReCOM) develop NP-SLE, including behavioral deficits prior to systemic autoimmunity, reduced brain volumes,...

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Detalles Bibliográficos
Autores principales: Makinde, Hadijat M., Winter, Deborah R., Procissi, Daniele, Mike, Elise V., Stock, Ariel D., Kando, Mary J., Gadhvi, Gaurav T., Droho, Steven, Bloomfield, Christina L., Dominguez, Salina T., Mayr, Maximilian G., Lavine, Jeremy A., Putterman, Chaim, Cuda, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055359/
https://www.ncbi.nlm.nih.gov/pubmed/32174913
http://dx.doi.org/10.3389/fimmu.2020.00230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055359/
https://www.ncbi.nlm.nih.gov/pubmed/32174913
http://dx.doi.org/10.3389/fimmu.2020.00230

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