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A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus
Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that SLE-prone mice (CReCOM) develop NP-SLE, including behavioral deficits prior to systemic autoimmunity, reduced brain volumes,...
Autores principales: | Makinde, Hadijat M., Winter, Deborah R., Procissi, Daniele, Mike, Elise V., Stock, Ariel D., Kando, Mary J., Gadhvi, Gaurav T., Droho, Steven, Bloomfield, Christina L., Dominguez, Salina T., Mayr, Maximilian G., Lavine, Jeremy A., Putterman, Chaim, Cuda, Carla M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055359/ https://www.ncbi.nlm.nih.gov/pubmed/32174913 http://dx.doi.org/10.3389/fimmu.2020.00230 |
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