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Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states
Transforming growth factor β-1 (TGFβ-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGFβ-1 is sequestration by its pro-peptide, latency-associated pep...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055372/ https://www.ncbi.nlm.nih.gov/pubmed/32148852 http://dx.doi.org/10.1107/S205225251901707X |