3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3

Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and inflammation. In addition to modulating endothelial proliferation and migratio...

Descripción completa

Detalles Bibliográficos
Autores principales: Wik, Jonas Aakre, Lundbäck, Peter, la Cour Poulsen, Lars, Haraldsen, Guttorm, Skålhegg, Bjørn Steen, Hol, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055879/
https://www.ncbi.nlm.nih.gov/pubmed/32130250
http://dx.doi.org/10.1371/journal.pone.0229395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055879/
https://www.ncbi.nlm.nih.gov/pubmed/32130250
http://dx.doi.org/10.1371/journal.pone.0229395

Ejemplares similares