Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy

Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity. Probabilistic models such as Bliss independence have been de...

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Detalles Bibliográficos
Autores principales: Comandante-Lou, Natacha, Khaliq, Mehwish, Venkat, Divya, Manikkam, Mohan, Fallahi-Sichani, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055924/
https://www.ncbi.nlm.nih.gov/pubmed/32084135
http://dx.doi.org/10.1371/journal.pcbi.1007688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055924/
https://www.ncbi.nlm.nih.gov/pubmed/32084135
http://dx.doi.org/10.1371/journal.pcbi.1007688

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