Cargando…
Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity. Probabilistic models such as Bliss independence have been de...
Autores principales: | Comandante-Lou, Natacha, Khaliq, Mehwish, Venkat, Divya, Manikkam, Mohan, Fallahi-Sichani, Mohammad |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055924/ https://www.ncbi.nlm.nih.gov/pubmed/32084135 http://dx.doi.org/10.1371/journal.pcbi.1007688 |
Ejemplares similares
-
Epigenetic modulation reveals differentiation state specificity of oncogene addiction
por: Khaliq, Mehwish, et al.
Publicado: (2021) -
Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency
por: Khaliq, Mehwish, et al.
Publicado: (2019) -
Dissecting cancer heterogeneity with a probabilistic genotype-phenotype model
por: Cho, Dong-Yeon, et al.
Publicado: (2013) -
Microleakage of Different Post Systems and a Custom Adapted Fiber Post
por: Geramipanah, Farideh, et al.
Publicado: (2013) -
Lipid Raft-Mediated Regulation of G-Protein Coupled Receptor Signaling by Ligands which Influence Receptor Dimerization: A Computational Study
por: Fallahi-Sichani, Mohammad, et al.
Publicado: (2009)