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Phenotype-based probabilistic analysis of heterogeneous responses to cancer drugs and their combination efficacy
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity. Probabilistic models such as Bliss independence have been de...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055924/ https://www.ncbi.nlm.nih.gov/pubmed/32084135 http://dx.doi.org/10.1371/journal.pcbi.1007688 |