Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning

Membrane proteins must balance the sequence constraints associated with folding and function against the hydrophobicity required for solvation within the bilayer. We recently found the expression and maturation of rhodopsin are limited by the hydrophobicity of its seventh transmembrane domain (TM7),...

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Detalles Bibliográficos
Autores principales: Penn, Wesley D., McKee, Andrew G., Kuntz, Charles P., Woods, Hope, Nash, Veronica, Gruenhagen, Timothy C., Roushar, Francis J., Chandak, Mahesh, Hemmerich, Chris, Rusch, Douglas B., Meiler, Jens, Schlebach, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056298/
https://www.ncbi.nlm.nih.gov/pubmed/32181350
http://dx.doi.org/10.1126/sciadv.aay7505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056298/
https://www.ncbi.nlm.nih.gov/pubmed/32181350
http://dx.doi.org/10.1126/sciadv.aay7505

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