Cargando…

Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors

Adenine base editors, which were developed by engineering a transfer RNA adenosine deaminase enzyme (TadA) into a DNA editing enzyme (TadA*), enable precise modification of A:T to G⋮C base pairs. Here, we use molecular dynamics simulations to uncover the structural and functional roles played by the...

Descripción completa

Detalles Bibliográficos
Autores principales: Rallapalli, Kartik L., Komor, Alexis C., Paesani, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056309/
https://www.ncbi.nlm.nih.gov/pubmed/32181363
http://dx.doi.org/10.1126/sciadv.aaz2309