Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice

Inversion of chromosome 16 (inv(16)) generates a fusion gene CBFB-MYH11, which is a driver mutation for acute myeloid leukemia (AML). Gene expression profiling suggests that Gata2, a hematopoietic transcription factor, is a top upregulated genes in preleukemic Cbfb-MYH11 knockin mice and is expresse...

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Detalles Bibliográficos
Autores principales: Saida, Satoshi, Zhen, Tao, Kim, Erika, Yu, Kai, Lopez, Guadalupe, McReynolds, Lisa J, Liu, Paul P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056539/
https://www.ncbi.nlm.nih.gov/pubmed/31624376
http://dx.doi.org/10.1038/s41375-019-0605-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056539/
https://www.ncbi.nlm.nih.gov/pubmed/31624376
http://dx.doi.org/10.1038/s41375-019-0605-7

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