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Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice

Inversion of chromosome 16 (inv(16)) generates a fusion gene CBFB-MYH11, which is a driver mutation for acute myeloid leukemia (AML). Gene expression profiling suggests that Gata2, a hematopoietic transcription factor, is a top upregulated genes in preleukemic Cbfb-MYH11 knockin mice and is expresse...

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Detalles Bibliográficos
Autores principales:	Saida, Satoshi, Zhen, Tao, Kim, Erika, Yu, Kai, Lopez, Guadalupe, McReynolds, Lisa J, Liu, Paul P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056539/ https://www.ncbi.nlm.nih.gov/pubmed/31624376 http://dx.doi.org/10.1038/s41375-019-0605-7

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