Local Irradiation Modulates the Pharmacokinetics of Metabolites in 5-Fluorouracil—Radiotherapy–Pharmacokinetics Phenomenon

BACKGROUND: The effects of radiotherapy (RT) on the pharmacokinetics (PK) of 5-FU and 5-fluoro-5,6-dihydro-uracil (5-FDHU) were investigated by animal experiments. METHODS: Whole-pelvis RT with 0.5 and 2 Gy was delivered to Sprague–Dawley rats. 5-FU at 100 mg/kg was intravenously infused 24 h after...

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Detalles Bibliográficos
Autores principales: Liu, Ju-Han, Tsai, Tung-Hu, Chen, Yu-Jen, Wang, Li-Ying, Liu, Hsin-Yu, Hsieh, Chen-Hsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056828/
https://www.ncbi.nlm.nih.gov/pubmed/32174836
http://dx.doi.org/10.3389/fphar.2020.00141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056828/
https://www.ncbi.nlm.nih.gov/pubmed/32174836
http://dx.doi.org/10.3389/fphar.2020.00141

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