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Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogen

BACKGROUND: Cancer cell metabolism can be characterised by adaptive metabolic alterations, which support abnormal proliferative cell growth with high energetic demand. De novo nucleotide biosynthesis is essential for providing nucleotides for RNA and DNA synthesis, and drugs targeting this biosynthe...

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Detalles Bibliográficos
Autores principales: Bayram, Safak, Fürst, Susanne, Forbes, Martin, Kempa, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056925/
https://www.ncbi.nlm.nih.gov/pubmed/31928927
http://dx.doi.org/10.1016/j.molmet.2019.12.002