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Thermal proteome profiling for interrogating protein interactions
Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat, proteins denature and become insoluble. Proteins can change their thermal stability upon interactions with small molecules (such as drugs or metabolites), nucleic acids or other proteins, or upon post‐translatio...
Autores principales: | Mateus, André, Kurzawa, Nils, Becher, Isabelle, Sridharan, Sindhuja, Helm, Dominic, Stein, Frank, Typas, Athanasios, Savitski, Mikhail M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057112/ https://www.ncbi.nlm.nih.gov/pubmed/32133759 http://dx.doi.org/10.15252/msb.20199232 |
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