Noonan syndrome‐associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish

BACKGROUND: Variants in the LZTR1 (leucine‐zipper‐like transcription regulator 1) gene (OMIM #600574) have been reported in recessive Noonan syndrome patients. In vivo evidence from animal models to support its causative role is lacking. METHODS: By CRISPR‐Cas9 genome editing, we generated lztr1‐mut...

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Detalles Bibliográficos
Autores principales: Nakagama, Yu, Takeda, Norihiko, Ogawa, Seishi, Takeda, Hiroyuki, Furutani, Yoshiyuki, Nakanishi, Toshio, Sato, Tatsuyuki, Hirata, Yoichiro, Oka, Akira, Inuzuka, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057116/
https://www.ncbi.nlm.nih.gov/pubmed/31883238
http://dx.doi.org/10.1002/mgg3.1107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057116/
https://www.ncbi.nlm.nih.gov/pubmed/31883238
http://dx.doi.org/10.1002/mgg3.1107

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