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Breast cancer pathogenesis is linked to the intra-tumoral estrogen sulfotransferase (hSULT1E1) expressions regulated by cellular redox dependent Nrf-2/NFκβ interplay

BACKGROUND: Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in pos...

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Detalles Bibliográficos
Autores principales: Nazmeen, Aarifa, Chen, Guangping, Ghosh, Tamal Kanti, Maiti, Smarajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057506/
https://www.ncbi.nlm.nih.gov/pubmed/32158360
http://dx.doi.org/10.1186/s12935-020-1153-y