Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity

BACKGROUND: Ovarian cancers often contain significant numbers of tumor-infiltrating lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy (ACT). However, the immunosuppressive ovarian tumor microenvironment and lack of tumor reactivity in TILs can limit the effectiveness of th...

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Detalles Bibliográficos
Autores principales: Santos, João Manuel, Heiniö, Camilla, Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Siurala, Mikko, Havunen, Riikka, Butzow, Ralf, Zafar, Sadia, de Gruijl, Tanja, Lassus, Heini, Kanerva, Anna, Hemminki, Akseli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057530/
https://www.ncbi.nlm.nih.gov/pubmed/31940588
http://dx.doi.org/10.1136/jitc-2019-000188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057530/
https://www.ncbi.nlm.nih.gov/pubmed/31940588
http://dx.doi.org/10.1136/jitc-2019-000188

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