Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring

BACKGROUND: Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smaller geno...

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Detalles Bibliográficos
Autores principales: Crowgey, Erin L., Mahajan, Nitin, Wong, Wing Hing, Gopalakrishnapillai, Anilkumar, Barwe, Sonali P., Kolb, E. Anders, Druley, Todd E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057603/
https://www.ncbi.nlm.nih.gov/pubmed/32131829
http://dx.doi.org/10.1186/s12920-020-0671-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057603/
https://www.ncbi.nlm.nih.gov/pubmed/32131829
http://dx.doi.org/10.1186/s12920-020-0671-8

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