Click Chemistry-Based Two-Component System for Efficient Inhibition of Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT)

[Image: see text] We synthesized two dTTP analogues for copper-free “click” chemistry-coupling in the active sites of DNA polymerases. We found that in the presence of both analogues, human immunodeficiency virus (HIV) reverse transcriptase (RT) activity was suppressed by up to 93%. This inhibitory...

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Detalles Bibliográficos
Autores principales: Ledezma, Carlos E., Cornett, Evan M., Kolpashchikov, Dmitry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057708/
https://www.ncbi.nlm.nih.gov/pubmed/32149246
http://dx.doi.org/10.1021/acsomega.9b03942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057708/
https://www.ncbi.nlm.nih.gov/pubmed/32149246
http://dx.doi.org/10.1021/acsomega.9b03942

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