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Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P(1B)-type ATPase, ATP7B

Intracellular copper (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of soluble metallochaperones that participate in Cu exchange through highly tuned protein-protein interactions. Recently, the human enzyme glutaredoxin-1 (hGrx1) has been shown to poss...

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Detalles Bibliográficos
Autores principales: Maghool, Shadi, Fontaine, Sharon La, Roberts, Blaine R., Kwan, Ann H., Maher, Megan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057996/
https://www.ncbi.nlm.nih.gov/pubmed/32139726
http://dx.doi.org/10.1038/s41598-020-60953-z