Development of a methodology to make individual estimates of the precision of liquid chromatography-tandem mass spectrometry drug assay results for use in population pharmacokinetic modeling and the optimization of dosage regimens

BACKGROUND: The clinical value of therapeutic drug monitoring can be increased most significantly by integrating assay results into clinical pharmacokinetic models for optimal dosing. The correct weighting in the modeling process is 1/variance, therefore, knowledge of the standard deviations (SD) of...

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Detalles Bibliográficos
Autores principales: Karvaly, Gellért Balázs, Neely, Michael N., Kovács, Krisztián, Vincze, István, Vásárhelyi, Barna, Jelliffe, Roger W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058336/
https://www.ncbi.nlm.nih.gov/pubmed/32134971
http://dx.doi.org/10.1371/journal.pone.0229873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058336/
https://www.ncbi.nlm.nih.gov/pubmed/32134971
http://dx.doi.org/10.1371/journal.pone.0229873

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