Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles

α-Klotho is a type 1 transmembrane protein that exhibits aging suppression function. The large amino-terminal extracellular domain of α-klotho is shed as soluble klotho (sKlotho) and functions as a circulating cardioprotective hormone. Diacylglycerol (DAG)-activated calcium-permeable TRPC6 channel p...

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Detalles Bibliográficos
Autores principales: Xie, Jian, An, Sung-Wan, Jin, Xin, Gui, Yuan, Huang, Chou-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058344/
https://www.ncbi.nlm.nih.gov/pubmed/32134975
http://dx.doi.org/10.1371/journal.pone.0229799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058344/
https://www.ncbi.nlm.nih.gov/pubmed/32134975
http://dx.doi.org/10.1371/journal.pone.0229799

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