Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al., 2017a). Here, we use the model to investigate mechanisms whereby immune checkpoint therapy for cancer paradoxically activ...

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Detalles Bibliográficos
Autores principales: Tezera, Liku B, Bielecka, Magdalena K, Ogongo, Paul, Walker, Naomi F, Ellis, Matthew, Garay-Baquero, Diana J, Thomas, Kristian, Reichmann, Michaela T, Johnston, David A, Wilkinson, Katalin Andrea, Ahmed, Mohamed, Jogai, Sanjay, Jayasinghe, Suwan N, Wilkinson, Robert J, Mansour, Salah, Thomas, Gareth J, Ottensmeier, Christian H, Leslie, Alasdair, Elkington, Paul T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058383/
https://www.ncbi.nlm.nih.gov/pubmed/32091388
http://dx.doi.org/10.7554/eLife.52668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058383/
https://www.ncbi.nlm.nih.gov/pubmed/32091388
http://dx.doi.org/10.7554/eLife.52668

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