A polygenic resilience score moderates the genetic risk for schizophrenia

Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited the existence of genetic variants that promote resilience to highly heritable p...

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Detalles Bibliográficos
Autores principales: Hess, Jonathan L., Tylee, Daniel S., Mattheisen, Manuel, Børglum, Anders D., Als, Thomas D., Grove, Jakob, Werge, Thomas, Mortensen, Preben Bo, Mors, Ole, Nordentoft, Merete, Hougaard, David M., Byberg-Grauholm, Jonas, Bækvad-Hansen, Marie, Greenwood, Tiffany A., Tsuang, Ming T., Curtis, David, Steinberg, Stacy, Sigurdsson, Engilbert, Stefánsson, Hreinn, Stefánsson, Kári, Edenberg, Howard J., Holmans, Peter, Faraone, Stephen V., Glatt, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058518/
https://www.ncbi.nlm.nih.gov/pubmed/31492941
http://dx.doi.org/10.1038/s41380-019-0463-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058518/
https://www.ncbi.nlm.nih.gov/pubmed/31492941
http://dx.doi.org/10.1038/s41380-019-0463-8

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