GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAF(V600E) Colorectal Cancer

Resistance to radiation and chemotherapy in colorectal cancer (CRC) patients contribute significantly to refractory disease and disease progression. Herein, we provide mechanistic rationale for acquired or inherent chemotherapeutic resistance to the anti-tumor effects of 5-fluorouracil (5-FU) that i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ruowen, Ma, Jinlu, Avery, Justin T., Sambandam, Vijaya, Nguyen, Theresa H., Xu, Bo, Suto, Mark J., Boohaker, Rebecca J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058788/
https://www.ncbi.nlm.nih.gov/pubmed/32185127
http://dx.doi.org/10.3389/fonc.2020.00241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058788/
https://www.ncbi.nlm.nih.gov/pubmed/32185127
http://dx.doi.org/10.3389/fonc.2020.00241

Ejemplares similares