Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown. We investigate here the involvement of A...

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Detalles Bibliográficos
Autores principales: Sierksma, Annerieke, Lu, Ashley, Mancuso, Renzo, Fattorelli, Nicola, Thrupp, Nicola, Salta, Evgenia, Zoco, Jesus, Blum, David, Buée, Luc, De Strooper, Bart, Fiers, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059012/
https://www.ncbi.nlm.nih.gov/pubmed/31951107
http://dx.doi.org/10.15252/emmm.201910606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059012/
https://www.ncbi.nlm.nih.gov/pubmed/31951107
http://dx.doi.org/10.15252/emmm.201910606

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