Cargando…

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown. We investigate here the involvement of A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sierksma, Annerieke, Lu, Ashley, Mancuso, Renzo, Fattorelli, Nicola, Thrupp, Nicola, Salta, Evgenia, Zoco, Jesus, Blum, David, Buée, Luc, De Strooper, Bart, Fiers, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059012/ https://www.ncbi.nlm.nih.gov/pubmed/31951107 http://dx.doi.org/10.15252/emmm.201910606

Ejemplares similares

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology
por: Sierksma, Annerieke, et al.
Publicado: (2018)

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
por: Salta, Evgenia, et al.
Publicado: (2016)

microRNA-132 regulates gene expression programs involved in microglial homeostasis
por: Walgrave, Hannah, et al.
Publicado: (2023)

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
por: Frigerio, Carlo Sala, et al.
Publicado: (2019)

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
por: Balusu, Sriram, et al.
Publicado: (2023)

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans
por: Thrupp, Nicola, et al.
Publicado: (2020)

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
por: Leonenko, Ganna, et al.
Publicado: (2021)

From Junk to Function: LncRNAs in CNS Health and Disease
por: Policarpo, Rafaela, et al.
Publicado: (2021)

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
por: Walgrave, Hannah, et al.
Publicado: (2021)

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
por: Laurent, Cyril, et al.
Publicado: (2018)

Alteration of the microRNA network during the progression of Alzheimer's disease
por: Lau, Pierre, et al.
Publicado: (2013)

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease
por: Gerrits, Emma, et al.
Publicado: (2021)

Increased tauopathy drives microglia-mediated clearance of beta-amyloid
por: Chen, Wesley, et al.
Publicado: (2016)

Microglia activation linking amyloid-β drive tau spatial propagation in Alzheimer's disease
por: Wang, Qing, et al.
Publicado: (2022)

Amyloid-β, p-tau and reactive microglia are pathological correlates of MRI cortical atrophy in Alzheimer’s disease
por: Frigerio, Irene, et al.
Publicado: (2021)

The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity
por: Obst, Juliane, et al.
Publicado: (2017)

Microglia in Alzheimer’s Disease in the Context of Tau Pathology
por: Perea, Juan Ramón, et al.
Publicado: (2020)

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
por: Lam, Suzanne, et al.
Publicado: (2021)

Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models
por: Faldini, Enrico, et al.
Publicado: (2019)

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease
por: Lemmens, Marijke A. M., et al.
Publicado: (2011)

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease
por: Pichet Binette, Alexa, et al.
Publicado: (2022)

MicroRNAs and the Regulation of Tau Metabolism
por: Hébert, Sébastien S., et al.
Publicado: (2012)

EuroTau: towing scientists to tau without tautology
por: Mudher, Amrit, et al.
Publicado: (2017)

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
por: Kim, Dong Won, et al.
Publicado: (2022)

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease
por: Kametani, Fuyuki, et al.
Publicado: (2018)

The Dichotomy of Alzheimer’s Disease Pathology: Amyloid-β and Tau
por: Ashford, J. Wesson
Publicado: (2019)

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
por: Hopp, Sarah C., et al.
Publicado: (2018)

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease
por: Gauvrit, Thibaut, et al.
Publicado: (2022)

Detection of Alzheimer's disease amyloid beta 1‐42, p‐tau, and t‐tau assays
por: van Harten, Argonde C., et al.
Publicado: (2021)

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis
por: Doens, Deborah, et al.
Publicado: (2014)

APOE and TREM2 regulate amyloid responsive microglia in Alzheimer’s disease
por: Nguyen, Aivi T., et al.
Publicado: (2020)

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection
por: Brown, Madeleine R., et al.
Publicado: (2020)

Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
por: Bischof, Gérard N., et al.
Publicado: (2016)

Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers
por: Lee, Jinny Claire, et al.
Publicado: (2019)

The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer’s Disease
por: Yin, Xiaomin, et al.
Publicado: (2021)

Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
por: Roda, Alejandro R., et al.
Publicado: (2022)

Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer’s Disease
por: Zhao, Yuanxin, et al.
Publicado: (2022)

Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
por: Lam, Suzanne, et al.
Publicado: (2022)

Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
por: Fixemer, Sonja, et al.
Publicado: (2022)

Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease
por: Calafate, Sara, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_clqo36bai0gj83amfe1g9bpvv0