Design, Synthesis and Biological Activity of 4,6-disubstituted Pyridin-2(1H)-ones as Novel Inhibitors of Soluble Epoxide Hydrolase

Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study,...

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Detalles Bibliográficos
Autores principales: Hejazi, Leila, Rezaee, Elham, Tabatabai, Sayyed Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059063/
https://www.ncbi.nlm.nih.gov/pubmed/32184844
http://dx.doi.org/10.22037/ijpr.2019.112047.13500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059063/
https://www.ncbi.nlm.nih.gov/pubmed/32184844
http://dx.doi.org/10.22037/ijpr.2019.112047.13500

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